These findings suggest that statin use does not materially compromise benefits of PSA-based screening. RISK THE GAME of Global Domination (PC, 1997) CD-ROM Game - EUR 7,30. Screening was associated with a lower incidence of metastatic tumors regardless of statin use.Ĭonclusion and Relevance In this post hoc subgroup analysis of a cohort from a population-based randomized clinical trial, PSA screening among statin users was associated with a decreased incidence of advanced prostate cancer that was similar among statin nonusers, but with less increase in detection of low-grade localized tumors in statin users than in nonusers. Incidence of low-risk (Gleason score 6) and localized tumors was lower among statin users, whereas detection of tumors with a Gleason score of 8 to 10 was similar. person-years) rate ratio, 1.31 95% CI, 1.24-1.38), no similar increase in incidence was observed among statin users (6.9 vs 5. Although PSA screening was associated with increased prostate cancer incidence among statin nonusers (screening vs control, 11.2 vs 8.
Results The study comprised 78 606 men (median age, 59 years ) with statin purchase data available. The analysis was stratified by statin use. Create a directory on your hard drive and copy all the files from the cdrom into that directory.
Main Outcomes and Measures Risk for prostate cancer overall, high-risk disease, and prostate cancer mortality in the screening group vs the control group as an intention-to-treat analysis. For the 1996 version from the original CDs - the installer will NOT work. Interventions Three invitations for PSA screening at 4-year intervals from 1996 to 2007 vs routine care. Data were analyzed from Januto March 31, 2021. Prevalent prostate cancer cases at baseline were excluded. Eligible men were identified from the population registry of Finland. Information on statin purchases from 1996 to 2009 was obtained from a national prescription registry. The population included all men aged 55 to 67 years at baseline and residing in the Tampere or Helsinki districts of Finland.
1996 risk pc trial#
Objective To investigate whether statin use was associated with outcomes of a randomized PSA-based prostate cancer screening intervention.ĭesign, Setting, and Participants This post hoc subgroup analysis of a cohort from a population-based randomized clinical trial used data from the population-based Finnish Randomized Study of Prostate Cancer Screening, which randomized men to PSA screening or routine care from March 1, 1996, to December 31, 1999, with follow-up continuing until December 31, 2015. Prostate-specific antigen levels are affected by use of cholesterol-lowering statin drugs, but the association of statin use with PSA screening performance is unknown. Infuriating cheaters that they are.Importance Prostate-specific antigen (PSA) screening for prostate cancer has resulted in a slight reduction in prostate cancer mortality but also a concomitant overdiagnosis of low-risk tumors. When an AI players conquers a continent, he is left practically undisturbed by the other AIs. But the fact is that they (they AI players) do that only versus the human players, while they absolutely don't act in the same way with each other. Also, all the AI players immediately attack the human player whenever he conquers a continent, and this is effectively good and challenging.
But an expert risk player notices all the "impossible " things that the AI does, like having always far better dice stats than the player in the long run (the in game graph statistics are not really useful, but I did mine manually), having reinforcements coming from nowhere, collecting cards (like it should be according to the original risk rules) while the player is unfairly forced to play immediately every combination he gets. Sadly, I've the impression that the programmer made the AI cheats attempting to challenge more the player. The game experience is totally infuriating in single player mode, and this comes from an expert Risk player, that wins tournaments against humans in real life.
It's a pity because the game is funny in multiplayer mode, but in single player mode the AI cheats too much.